Phytochemical-based nanodrug delivery in cancer therapy

Waleed Hassan Almalki; Najla Nasser Alotaibi; Abdulrahman Abdullah Muhammad Alayaf; Abdullah Fahd Alotaibi; Mohamed Awad Althubiti

doi:10.53730/ijhs.v6nS1.6134

Authors

Waleed Hassan Almalki
Whmalki@uqu.edu.sa
Professor, Department of Pharmacology and Toxicology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia
Najla Nasser Alotaibi Research Scholar, Al Hada Armed Forces Hospital, Pharmaceutical CARE Department - Ministry of Defense, Taif, Saudi Arabia
Abdulrahman Abdullah Muhammad Alayaf Research Scholar, Medical Services Department, Ministry of Interior, Jeddah, Saudi Arabia
Abdullah Fahd Alotaibi Research Scholar, Medical Services Department, Ministry of Interior, Jeddah, Saudi Arabia
Mohamed Awad Althubiti Research Scholar, Medical Services Department, Ministry of Interior, Jeddah, Saudi Arabia

Keywords:

nanocarrier, cancer, phytochemicals, cancer prevention

Abstract

There are estimated to be 13.1 million cancer deaths by 2030, with 7.6 million deaths occurring each year. Phytochemicals have long been used in traditional medicine to cure cancer. However, conventional therapy for metastatic illness may fail if cancer cells become resistant to multiple anticancer drugs. Phytochemicals encapsulated in nano-based medication delivery devices were studied for their cancer- and chemo-preventive properties. Nanocarriers containing phytoconstituents have been studied in terms of loading efficiency, nanocarrier size, the release profile of the drug, and cell inhibition and treatment tests.

Downloads

Download data is not yet available.

References

Afifi-Yazar, F. U., Kasabri, V., & Abu-Dahab, R. (2011). Medicinal plants from Jordan in the treatment of cancer: traditional uses vs. in vitro and in vivo evaluations--part 1. Planta Med, 77(11), 1203-1209. DOI: https://doi.org/10.1055/s-0030-1270832

Agyare, C., Spiegler, V., Asase, A., Scholz, M., Hempel, G., & Hensel, A. (2018). An ethnopharmacological survey of medicinal plants traditionally used for cancer treatment in the Ashanti region, Ghana. J Ethnopharmacol, 212, 137-152. DOI: https://doi.org/10.1016/j.jep.2017.10.019

Ahmadi, E. S., Tajbakhsh, A., Iranshahy, M., Asili, J., Kretschmer, N., Shakeri, A., & Sahebkar, A. (2020). Naphthoquinone Derivatives Isolated from Plants: Recent Advances in Biological Activity. Mini Rev Med Chem, 20(19), 2019-2035. DOI: https://doi.org/10.2174/1389557520666200818212020

Akhtar, M. F., Saleem, A., Alamgeer, & Saleem, M. (2019). A Comprehensive Review on Ethnomedicinal, Pharmacological and Phytochemical Basis of Anticancer Medicinal Plants of Pakistan. Curr Cancer Drug Targets, 19(2), 120-151. DOI: https://doi.org/10.2174/1568009618666180706164536

Akkol, E. K., Dereli, F. T. G., Sobarzo-Sánchez, E., & Khan, H. (2020). Roles of Medicinal Plants and Constituents in Gynecological Cancer Therapy: Current Literature and Future Directions. Curr Top Med Chem, 20(20), 1772-1790. DOI: https://doi.org/10.2174/1568026620666200416084440

Alami Merrouni, I., & Elachouri, M. (2021). Anticancer medicinal plants used by Moroccan people: Ethnobotanical, preclinical, phytochemical and clinical evidence. J Ethnopharmacol, 266, 113435. DOI: https://doi.org/10.1016/j.jep.2020.113435

Almatroodi, S. A., Almatroudi, A., Alsahli, M. A., Khan, A. A., & Rahmani, A. H. (2020). Thymoquinone, an Active Compound of Nigella sativa: Role in Prevention and Treatment of Cancer. Curr Pharm Biotechnol, 21(11), 1028-1041. DOI: https://doi.org/10.2174/1389201021666200416092743

Alonso-Castro, A. J., Villarreal, M. L., Salazar-Olivo, L. A., Gomez-Sanchez, M., Dominguez, F., & Garcia-Carranca, A. (2011). Mexican medicinal plants used for cancer treatment: pharmacological, phytochemical and ethnobotanical studies. J Ethnopharmacol, 133(3), 945-972. DOI: https://doi.org/10.1016/j.jep.2010.11.055

Asemani, Y., Zamani, N., Bayat, M., & Amirghofran, Z. (2019). Allium vegetables for possible future of cancer treatment. Phytother Res, 33(12), 3019-3039. DOI: https://doi.org/10.1002/ptr.6490

Aune, D. (2019). Plant Foods, Antioxidant Biomarkers, and the Risk of Cardiovascular Disease, Cancer, and Mortality: A Review of the Evidence. Adv Nutr, 10(Suppl_4), S404-s421. DOI: https://doi.org/10.1093/advances/nmz042

Balachandran, P., & Govindarajan, R. (2005). Cancer--an ayurvedic perspective. Pharmacological research, 51(1), 19-30. DOI: https://doi.org/10.1016/j.phrs.2004.04.010

Benarba, B., & Pandiella, A. (2018). Colorectal cancer and medicinal plants: Principle findings from recent studies. Biomed Pharmacother, 107, 408-423. DOI: https://doi.org/10.1016/j.biopha.2018.08.006

Bhatnagar, I., Thomas, N. V., & Kim, S. K. (2013). Natural flora and anticancer regime: milestones and roadmap. Anticancer Agents Med Chem, 13(6), 910-922. DOI: https://doi.org/10.2174/18715206113139990125

Blažejová, R., & Hošek, J. (2019). Plant-derived drugs and their applicaction in the anticancer therapy. Ceska Slov Farm, 68(1), 3-11.

Bouhaous, L., Miara, M. D., Bendif, H., & Souilah, N. (2022). Medicinal plants used by patients to fight cancer in northwestern Algeria. Bull Cancer, 109(3), 296-306. DOI: https://doi.org/10.1016/j.bulcan.2021.09.017

Buyel, J. F. (2018). Plants as sources of natural and recombinant anti-cancer agents. Biotechnol Adv, 36(2), 506-520. DOI: https://doi.org/10.1016/j.biotechadv.2018.02.002

Caamal-Fuentes, E., Torres-Tapia, L. W., Simá-Polanco, P., Peraza-Sánchez, S. R., & Moo-Puc, R. (2011). Screening of plants used in Mayan traditional medicine to treat cancer-like symptoms. J Ethnopharmacol, 135(3), 719-724. DOI: https://doi.org/10.1016/j.jep.2011.04.004

Calderón-Montaño, J. M., Burgos-Morón, E., Pérez-Guerrero, C., & López-Lázaro, M. (2011). A review on the dietary flavonoid kaempferol. Mini Rev Med Chem, 11(4), 298-344. DOI: https://doi.org/10.2174/138955711795305335

Cragg, G. M., & Newman, D. J. (2005). Plants as a source of anti-cancer agents. J Ethnopharmacol, 100(1-2), 72-79. DOI: https://doi.org/10.1016/j.jep.2005.05.011

Dai, S. X., Li, W. X., Han, F. F., Guo, Y. C., Zheng, J. J., Liu, J. Q., . . . Huang, J. F. (2016). In silico identification of anti-cancer compounds and plants from traditional Chinese medicine database. Sci Rep, 6, 25462. DOI: https://doi.org/10.1038/srep25462

Dang, L., & Van Damme, E. J. M. (2015). Toxic proteins in plants. Phytochemistry, 117, 51-64. DOI: https://doi.org/10.1016/j.phytochem.2015.05.020

Dávalos, A., Pinilla, L., López de Las Hazas, M. C., Pinto-Hernández, P., Barbé, F., Iglesias-Gutiérrez, E., & de Gonzalo-Calvo, D. (2021). Dietary microRNAs and cancer: A new therapeutic approach? Semin Cancer Biol, 73, 19-29. DOI: https://doi.org/10.1016/j.semcancer.2020.10.006

Desai, A. G., Qazi, G. N., Ganju, R. K., El-Tamer, M., Singh, J., Saxena, A. K., . . . Bhat, H. K. (2008). Medicinal plants and cancer chemoprevention. Curr Drug Metab, 9(7), 581-591. DOI: https://doi.org/10.2174/138920008785821657

Devadasan, V., Raman, P., & Dasararaju, G. (2021). Anti-Cancer Compounds from Terrestrial and Marine Resources -In silico and Experimental Studies. Curr Comput Aided Drug Des, 17(7), 865-880. DOI: https://doi.org/10.2174/1573409916666200910140801

Devi, B., Kumar, Y., Shrivastav, B., Sharma, G. N., Gupta, G., & Dua, K. (2018). Current updates on biological and pharmacological activities of doxycycline. Panminerva Medica, 60(1), 36-39. DOI: https://doi.org/10.23736/S0031-0808.18.03398-0

Devkota, H. P., Adhikari-Devkota, A., Paudel, K. R., Panth, N., Gupta, G., Chellappan, D. K., . . . Dua, K. (2022). Phytochemicals and their Nanoformulations Targeted for Pulmonary Diseases. Advanced Drug Delivery Strategies for Targeting Chronic Inflammatory Lung Diseases, 95. DOI: https://doi.org/10.1007/978-981-16-4392-7_5

Dua, K., Gupta, G., Chellappan, D., Bebawy, M., & Collet, T. (2018). Nanoparticle-based therapies as a modality in treating wounds and preventing biofilm. Panminerva Medica: a Journal on Internal Medicine, 60(4), 237-238. DOI: https://doi.org/10.23736/S0031-0808.18.03435-3

Dua, K., Gupta, G., Rao, N. K., & Bebawy, M. (2018). Nano-antibiotics: a novel approach in treating P. aeruginosa biofilm infections. Minerva medica, 109(5), 400. DOI: https://doi.org/10.23736/S0026-4806.18.05588-X

El-Harakeh, M., Al-Ghadban, S., & Safi, R. (2021). Medicinal Plants Towards Modeling Skin Cancer. Curr Drug Targets, 22(2), 148-161. DOI: https://doi.org/10.2174/1389450121666201005103521

El Omari, N., Bakha, M., Imtara, H., Guaouguaoua, F. E., Balahbib, A., Zengin, G., & Bouyahya, A. (2021). Anticancer mechanisms of phytochemical compounds: focusing on epigenetic targets. Environ Sci Pollut Res Int, 28(35), 47869-47903. DOI: https://doi.org/10.1007/s11356-021-15594-8

Epifano, F., Curini, M., Marcotullio, M. C., & Genovese, S. (2011). Searching for novel cancer chemopreventive plants and their products: the genus Zanthoxylum. Curr Drug Targets, 12(13), 1895-1902. DOI: https://doi.org/10.2174/138945011798184128

Garima, S., Ajit Kumar, P., Marcy, D. M., Sakthivel, R., Bhim Pratap, S., & Nachimuthu Senthil, K. (2020). Ethnobotanical survey of medicinal plants used in the management of cancer and diabetes. J Tradit Chin Med, 40(6), 1007-1017.

George, V. C., Dellaire, G., & Rupasinghe, H. P. V. (2017). Plant flavonoids in cancer chemoprevention: role in genome stability. J Nutr Biochem, 45, 1-14. DOI: https://doi.org/10.1016/j.jnutbio.2016.11.007

Gezici, S., & Şekeroğlu, N. (2019). Current Perspectives in the Application of Medicinal Plants Against Cancer: Novel Therapeutic Agents. Anticancer Agents Med Chem, 19(1), 101-111. DOI: https://doi.org/10.2174/1871520619666181224121004

Graham, J. G., Quinn, M. L., Fabricant, D. S., & Farnsworth, N. R. (2000). Plants used against cancer - an extension of the work of Jonathan Hartwell. J Ethnopharmacol, 73(3), 347-377. DOI: https://doi.org/10.1016/S0378-8741(00)00341-X

Greenwald, P. (1996). Chemoprevention of cancer. Sci Am, 275(3), 96-99. DOI: https://doi.org/10.1038/scientificamerican0996-96

Gul, K., Singh, A. K., & Jabeen, R. (2016). Nutraceuticals and Functional Foods: The Foods for the Future World. Crit Rev Food Sci Nutr, 56(16), 2617-2627. DOI: https://doi.org/10.1080/10408398.2014.903384

Gupta, G., Kazmi, I., Afzal, M., Rahman, M., Saleem, S., Ashraf, M. S., . . . Mujeeb, M. (2012). Sedative, antiepileptic and antipsychotic effects of Viscum album L.(Loranthaceae) in mice and rats. Journal of Ethnopharmacology, 141(3), 810-816. DOI: https://doi.org/10.1016/j.jep.2012.03.013

Gupta, G., Pathak, S., Dahiya, R., Awasthi, R., Mishra, A., Sharma, R. K., . . . Dua, K. (2019). Aqueous extract of wood ear mushroom, Auricularia polytricha (Agaricomycetes), demonstrated antiepileptic activity against seizure induced by maximal electroshock and isoniazid in experimental animals. International journal of medicinal mushrooms, 21(1). DOI: https://doi.org/10.1615/IntJMedMushrooms.2018029113

Hartwell, J. L. (1969). Plants used against cancer. A survey. Lloydia, 32(3), 247-296.

Hartwell, J. L. (1971). Plants used against cancer. A survey. Lloydia, 34(1), 103-160.

Hasanpourghadi, M., Looi, C. Y., Pandurangan, A. K., Sethi, G., Wong, W. F., & Mustafa, M. R. (2017). Phytometabolites Targeting the Warburg Effect in Cancer Cells: A Mechanistic Review. Curr Drug Targets, 18(9), 1086-1094. DOI: https://doi.org/10.2174/1389450117666160401124842

Hatware, K. V., Sharma, S., Patil, K., Rajput, H., & Gupta, G. (2020). Therapeutic role of natural agents in the management of coronary artery disease: a review. Journal of Environmental Pathology, Toxicology and Oncology, 39(2). DOI: https://doi.org/10.1615/JEnvironPatholToxicolOncol.2020033025

Hazafa, A., Rehman, K. U., Jahan, N., & Jabeen, Z. (2020). The Role of Polyphenol (Flavonoids) Compounds in the Treatment of Cancer Cells. Nutr Cancer, 72(3), 386-397. DOI: https://doi.org/10.1080/01635581.2019.1637006

Hemrajani, C., Negi, P., Parashar, A., Gupta, G., Jha, N. K., Singh, S. K., . . . Dua, K. (2022). Overcoming drug delivery barriers and challenges in topical therapy of atopic dermatitis: A nanotechnological perspective. Biomedicine & Pharmacotherapy, 147, 112633. DOI: https://doi.org/10.1016/j.biopha.2022.112633

Henderson, B. E., Ross, R. K., & Pike, M. C. (1991). Toward the primary prevention of cancer. Science, 254(5035), 1131-1138. DOI: https://doi.org/10.1126/science.1957166

Hilker, M., & Meiners, T. (2011). Plants and insect eggs: how do they affect each other? Phytochemistry, 72(13), 1612-1623. DOI: https://doi.org/10.1016/j.phytochem.2011.02.018

Hussain, T., Bajpai, S., Saeed, M., Moin, A., Alafnan, A., Khan, M., . . . Ashraf, G. M. (2018). Potentiating Effect of Ethnomedicinal Plants Against Proliferation on Different Cancer Cell Lines. Curr Drug Metab, 19(7), 584-595. DOI: https://doi.org/10.2174/1389200219666180305144841

Kazmi, I., Afzal, M., Gupta, G., & Anwar, F. (2012). Antiepileptic potential of ursolic acid stearoyl glucoside by GABA receptor stimulation. CNS neuroscience & therapeutics, 18(9), 799. DOI: https://doi.org/10.1111/j.1755-5949.2012.00369.x

Khalid, E. B., Ayman, E. E., Rahman, H., Abdelkarim, G., & Najda, A. (2016). Natural products against cancer angiogenesis. Tumour Biol, 37(11), 14513-14536. DOI: https://doi.org/10.1007/s13277-016-5364-8

Khan, A., Ali, S., Murad, W., Hayat, K., Siraj, S., Jawad, M., . . . Khan, A. (2021). Phytochemical and pharmacological uses of medicinal plants to treat cancer: A case study from Khyber Pakhtunkhwa, North Pakistan. J Ethnopharmacol, 281, 114437. DOI: https://doi.org/10.1016/j.jep.2021.114437

Khan, T., Ali, M., Khan, A., Nisar, P., Jan, S. A., Afridi, S., & Shinwari, Z. K. (2019). Anticancer Plants: A Review of the Active Phytochemicals, Applications in Animal Models, and Regulatory Aspects. Biomolecules, 10(1). DOI: https://doi.org/10.3390/biom10010047

Klein-Júnior, L. C., Campos, A., Niero, R., Corrêa, R., Vander Heyden, Y., & Filho, V. C. (2020). Xanthones and Cancer: from Natural Sources to Mechanisms of Action. Chem Biodivers, 17(2), e1900499. DOI: https://doi.org/10.1002/cbdv.201900499

Kooti, W., Servatyari, K., Behzadifar, M., Asadi-Samani, M., Sadeghi, F., Nouri, B., & Zare Marzouni, H. (2017). Effective Medicinal Plant in Cancer Treatment, Part 2: Review Study. J Evid Based Complementary Altern Med, 22(4), 982-995. DOI: https://doi.org/10.1177/2156587217696927

Kostecka, L. G., Pienta, K. J., & Amend, S. R. (2021). Lipid droplet evolution gives insight into polyaneuploid cancer cell lipid droplet functions. Med Oncol, 38(11), 133. DOI: https://doi.org/10.1007/s12032-021-01584-w

Kumar Chellappan, D., Yenese, Y., Chian Wei, C., & Gupta, G. (2017). Nanotechnology and diabetic wound healing: a review. Endocrine, Metabolic & Immune Disorders-Drug Targets (Formerly Current Drug Targets-Immune, Endocrine & Metabolic Disorders), 17(2), 87-95. DOI: https://doi.org/10.2174/1871530317666170421121202

Luís, Â., Domingues, F., & Duarte, A. P. (2016). Biological Properties of Plant-Derived Alkylresorcinols: Mini-Review. Mini Rev Med Chem, 16(11), 851-854. DOI: https://doi.org/10.2174/1389557516666160211121437

Mathur, M., & Vyas, G. (2013). Role of nanoparticles for production of smart herbal drug-An overview. Indian Journal of Natural Products and Resources, 4, 329-338.

Matowa, P. R., Gundidza, M., Gwanzura, L., & Nhachi, C. F. B. (2020). A survey of ethnomedicinal plants used to treat cancer by traditional medicine practitioners in Zimbabwe. BMC Complement Med Ther, 20(1), 278. DOI: https://doi.org/10.1186/s12906-020-03046-8

Mayzlish-Gati, E., Fridlender, M., Nallathambi, R., Selvaraj, G., Nadarajan, S., & Koltai, H. (2018). Review on Anti-Cancer Activity in Wild Plants of the Middle East. Curr Med Chem, 25(36), 4656-4670. DOI: https://doi.org/10.2174/0929867324666170705113129

Mbele, M., Hull, R., & Dlamini, Z. (2017). African medicinal plants and their derivatives: Current efforts towards potential anti-cancer drugs. Exp Mol Pathol, 103(2), 121-134. DOI: https://doi.org/10.1016/j.yexmp.2017.08.002

Miller, P. E., & Snyder, D. C. (2012). Phytochemicals and cancer risk: a review of the epidemiological evidence. Nutr Clin Pract, 27(5), 599-612. DOI: https://doi.org/10.1177/0884533612456043

Muchakayala, S. K., Katari, N. K., Dongala, T., Marisetti, V. M., Vyas, G., & Vegesna, R. V. K. (2022). Eco-friendly and green chromatographic method for the simultaneous determination of chlorocresol and betamethasone dipropionate in topical formulations using Box–Behnken design. Journal of the Iranian Chemical Society, 19(4), 1397-1412. DOI: https://doi.org/10.1007/s13738-021-02388-5

Muniyandi, K., George, B., Parimelazhagan, T., & Abrahamse, H. (2020). Role of Photoactive Phytocompounds in Photodynamic Therapy of Cancer. Molecules, 25(18). DOI: https://doi.org/10.3390/molecules25184102

Nessa, M. U., Rahman, M. A., & Kabir, Y. (2020). Plant-Produced Monoclonal Antibody as Immunotherapy for Cancer. Biomed Res Int, 2020, 3038564. DOI: https://doi.org/10.1155/2020/3038564

Patel, S. (2016). Emerging Adjuvant Therapy for Cancer: Propolis and its Constituents. J Diet Suppl, 13(3), 245-268. DOI: https://doi.org/10.3109/19390211.2015.1008614

Patil, K. R., Goyal, S. N., Sharma, C., Patil, C. R., & Ojha, S. (2015). Phytocannabinoids for Cancer Therapeutics: Recent Updates and Future Prospects. Curr Med Chem, 22(30), 3472-3501. DOI: https://doi.org/10.2174/0929867322666150716115057

Rahimian, N., Miraei, H. R., Amiri, A., Ebrahimi, M. S., Nahand, J. S., Tarrahimofrad, H., . . . Mirzaei, H. (2021). Plant-based vaccines and cancer therapy: Where are we now and where are we going? Pharmacological research, 169, 105655. DOI: https://doi.org/10.1016/j.phrs.2021.105655

Raimi, I. O., Kopaopa, B. G., Mugivhisa, L. L., Lewu, F. B., Amoo, S. O., & Olowoyo, J. O. (2021). An ethnobotanical survey of medicinal plants used by traditional healers for the treatment of cancer in Hammanskraal and Winterveld, Tshwane Metropolitan Municipality, South Africa. Afr Health Sci, 21(4), 1746-1753. DOI: https://doi.org/10.4314/ahs.v21i4.31

Rajabi, S., Maresca, M., Yumashev, A. V., Choopani, R., & Hajimehdipoor, H. (2021). The Most Competent Plant-Derived Natural Products for Targeting Apoptosis in Cancer Therapy. Biomolecules, 11(4). DOI: https://doi.org/10.3390/biom11040534

Ramprasath, V. R., & Awad, A. B. (2015). Role of Phytosterols in Cancer Prevention and Treatment. J AOAC Int, 98(3), 735-738. DOI: https://doi.org/10.5740/jaoacint.SGERamprasath

Roy, M., Mukherjee, A., Sarkar, R., Mukherjee, S., & Biswas, J. (2015). In search of natural remediation for cervical cancer. Anticancer Agents Med Chem, 15(1), 57-65. DOI: https://doi.org/10.2174/1871520614666140722084154

Salehi, B., Varoni, E. M., Sharifi-Rad, M., Rajabi, S., Zucca, P., Iriti, M., & Sharifi-Rad, J. (2019). Epithelial-mesenchymal transition as a target for botanicals in cancer metastasis. Phytomedicine, 55, 125-136. DOI: https://doi.org/10.1016/j.phymed.2018.07.001

Salehi, B., Zucca, P., Sharifi-Rad, M., Pezzani, R., Rajabi, S., Setzer, W. N., . . . Sharifi-Rad, J. (2018). Phytotherapeutics in cancer invasion and metastasis. Phytother Res, 32(8), 1425-1449. DOI: https://doi.org/10.1002/ptr.6087

Salmerón-Manzano, E., Garrido-Cardenas, J. A., & Manzano-Agugliaro, F. (2020). Worldwide Research Trends on Medicinal Plants. Int J Environ Res Public Health, 17(10). DOI: https://doi.org/10.3390/ijerph17103376

Samadi, P., Sarvarian, P., Gholipour, E., Asenjan, K. S., Aghebati-Maleki, L., Motavalli, R., . . . Yousefi, M. (2020). Berberine: A novel therapeutic strategy for cancer. IUBMB Life, 72(10), 2065-2079. DOI: https://doi.org/10.1002/iub.2350

Seca, A. M. L., & Pinto, D. (2018). Plant Secondary Metabolites as Anticancer Agents: Successes in Clinical Trials and Therapeutic Application. Int J Mol Sci, 19(1). DOI: https://doi.org/10.3390/ijms19010263

Shawky, E. (2019). Prediction of potential cancer-related molecular targets of North African plants constituents using network pharmacology-based analysis. J Ethnopharmacol, 238, 111826. DOI: https://doi.org/10.1016/j.jep.2019.111826

Shin, S. A., Moon, S. Y., Kim, W. Y., Paek, S. M., Park, H. H., & Lee, C. S. (2018). Structure-Based Classification and Anti-Cancer Effects of Plant Metabolites. Int J Mol Sci, 19(9). DOI: https://doi.org/10.3390/ijms19092651

Shlyakhovenko, V. O. (2016). Ribonucleases. Possible new approach in cancer therapy. Exp Oncol, 38(1), 2-8. DOI: https://doi.org/10.31768/2312-8852.2016.38(1):2-8

Slobodníková, L., Fialová, S., Rendeková, K., Kováč, J., & Mučaji, P. (2016). Antibiofilm Activity of Plant Polyphenols. Molecules, 21(12). DOI: https://doi.org/10.3390/molecules21121717

Subramaniam, S., Selvaduray, K. R., & Radhakrishnan, A. K. (2019). Bioactive Compounds: Natural Defense Against Cancer? Biomolecules, 9(12). DOI: https://doi.org/10.3390/biom9120758

Subramanian, V. B., Katari, N. K., Ponnam, V., Konduru, N., Dongala, T., Marisetti, V. M., & Vyas, G. (2022). Stability-indicating reversed-phase-HPLC method development and validation for sacubitril/valsartan complex in the presence of impurities and degradation products: Robustness by quality-by-design approach. Biomed Chromatogr, 36(1), e5240. DOI: https://doi.org/10.1002/bmc.5240

Valluri, V., Katari, N., Khatri, C., Vyas, G., Polagani, S., & Ponnam, V. (2021). Highly sensitive liquid chromatography–tandem mass spectrometry assay for the determination of azathioprine in presence of mercaptopurine and its application to a human pharmacokinetic study. Separation Science Plus, 4. DOI: https://doi.org/10.1002/sscp.202100022

Vyas, G., Mathur, M., Patel, N. A., & Patel, R. P. (2017). Aphrodisiac Efficacy of Blepharis sindica seeds: A comparative assessment using different solvent types. Indian journal of biochemistry & biophysics, 54, 223-230.