Intralesional penicillamine in the treatment of keloids and hypertrophic scars
Open labeled therapeutic trial
Keywords:
Intralesional penicillamine, Keloid, Hypertrophic scarsAbstract
Background: Many therapeutic options have been tried in the treatment of keloid and hypertrophic scars, but no one is superior to others. Penicillamine has been used systemically but not tested as intralesional. Objective: The aim of this study was to evaluate the effectiveness & safety of intralesional penicillamine for treatment of keloids and hypertrophic scars. Patients and Method: this is open labeled therapeutic trial study encountered in Department of Dermatology and Venereology in Al-Yarmouk teaching Hospital, Baghdad-Iraq. Collection of data was carried out during the period between May 2010 – February 2011. This study included 28 patients with keloids and hypertrophic scars. Penicillamine was prepared as a solution for intralesional injection by dissolving (250mg) of Penicillamine (Artamin)® by SANDOZ in (10ml) distilled water in sterilized container to obtained (2.5%) concentration of Penicillamine and autoclaved at 121C0 for 20 min before use. Penicillamine was administered with 27-gauge needle syringe without anesthesia. Seventy percent ethanol was used as an antiseptic agent before injection. Four sessions of intralesional injection were given at intervals of 15 days each.
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