Determination of valsartan in its pharmaceutical preparations using high-performance liquid chromatography technique
Keywords:
high-performance, liquid chromatography, valsartanAbstract
High-performance liquid chromatography technique was used to estimate valsartan in its pure form and in some pharmaceutical preparations. It was found through the results obtained that the proposed method is sensitive and accurate, and the estimation was done in a short time. In this work, a No L1, 150mm separation column was used to separate the components as they were type The UV spectrometer was used as a wavelength of 239 nm, the column temperature was 40°C, and the mobile phase consisted of 50:50 (acetonitrile: methanol: drops of triethylamine, pH = 2.4) at a flow rate of 1 ml/min. Through what was reached, we find that the method is sensitive, accurate and compatible, as the percentage recovery reached (100.63-103.35), and the linearity was (40-120 mcg/ml) for valsartan. The method was applied to a number of pharmaceutical preparations available in the local market, and the method was successful in the quantitative estimation of valsartan.
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