Risk factors for autoimmune hemolytic anemia in children with transfusion-dependent thalassemia at a tertiary referral hospital
A cross-sectional study
Keywords:
transfusion-dependent thalassemia, autoimmune hemolytic anemia, risk factors, children, anemiaAbstract
Repeated transfusions of children with transfusion-dependent thalassemia (TDT) save their lives while causing complications such as the development of autoimmune hemolytic anemia (AIHA). Studies regarding this matter have not yet been extensively reviewed. Therefore, we aim to assess the risk factors of developing AIHA in children with TDT.
Downloads
References
Permono B, Sutaryo, S., Ugrasena, IDG., Windiastuti, E. Buku Ajar Hematologi-Onkologi Anak. Jakarta: Badan Penerbit IDAI., 2012.
Sari TT, Gatot D, Akib AAP, et al. Immune response of thalassemia major patients in Indonesia with and without splenectomy. Acta Medica Indonesiana 2016; 46.
Wahidiyat I. Thalassemia dan permasalahannya di Indonesia. Sari Pediatri 2016; 5: 2-3.
Datta SS, Mukherjee S, Talukder B, et al. Frequency of red cell alloimmunization and autoimmunization in thalassemia patients: a report from Eastern India. Advances in hematology 2015; 2015.
Dhawan HK, Kumawat V, Marwaha N, et al. Alloimmunization and autoimmunization in transfusion dependent thalassemia major patients: Study on 319 patients. Asian journal of transfusion science 2014; 8: 84.
Dogra A, Sidhu M, Kapoor R, et al. Study of red blood cell alloimmunization in multitransfused thalassemic children of Jammu region. Asian Journal of Transfusion Science 2015; 9: 78.
Khaled MB, Ouederni M, Sahli N, et al. Predictors of autoimmune hemolytic anemia in beta-thalassemia patients with underlying red blood cells autoantibodies. Blood Cells, Molecules, and Diseases 2019; 79: 102342.
Al-Mousawi MMN, Al-Allawi NAS and Alnaqshabandi R. Predictors of red cell alloimmunization in Kurdish multi transfused patients with hemoglobinopathies in Iraq. Hemoglobin 2015; 39: 423-426.
Karimi M, Nikrooz P, Kashef S, et al. RBC alloimmunization in blood transfusion‐dependent β‐thalassemia patients in southern Iran. International journal of laboratory hematology 2007; 29: 321-326.
Singer ST, Wu V, Mignacca R, et al. Alloimmunization and erythrocyte autoimmunization in transfusion-dependent thalassemia patients of predominantly Asian descent. Blood, The Journal of the American Society of Hematology 2000; 96: 3369-3373.
Ahmed Kiani R, Anwar M, Waheed U, et al. Epidemiology of transfusion transmitted infection among patients with β-thalassaemia major in Pakistan. Journal of blood transfusion 2016; 2016.
Michail‐Merianou V, Pamphili‐Panousopoulou L, Piperi‐Lowes L, et al. Alloimmunization to red cell antigens in thalassemia: comparative study of usual versus better‐match transfusion programmes. Vox sanguinis 1987; 52: 95-98.
Spanos TH, Karageorga M, Ladis V, et al. Red cell alloantibodies in patients with thalassemia. Vox sanguinis 1990; 58: 50-55.
El Kababi S, Benajiba M, El Khalfi B, et al. Red blood cell alloimmunizations in beta-thalassemia patients in Casablanca/Morocco: Prevalence and risk factors. Transfusion Clinique et Biologique 2019; 26: 240-248.
Koçyiğit C, Eliaçık K, Kanık A, et al. Frequency of red cell allo-and autoimmunization in patients with transfusion-dependent beta thalassemia and affecting factors. Turk J Pediatr 2014; 56: 487-492.
Kuczmarski RJ. 2000 CDC Growth Charts for the United States: methods and development. Department of Health and Human Services, Centers for Disease Control and …, 2002.
Merritt RJ and Suskind RM. Nutritional survey of hospitalized pediatric patients. The American Journal of Clinical Nutrition 1979; 32: 1320-1325.
World Health O. WHO child growth standards: length/height-for-age, weight-for-age, weight-for-length, weight-for-height and body mass index-for-age: methods and development. World Health Organization, 2006.
Cappellini M-D, Cohen A, Porter J, et al. Guidelines for the management of transfusion dependent thalassaemia (TDT). Thalassaemia International Federation Nicosia, Cyprus, 2014.
Abdelrazik AM, Elshafie SM, El Said MN, et al. Study of red blood cell alloimmunization risk factors in multiply transfused thalassemia patients: role in improving thalassemia transfusion practice in Fayoum, Egypt. Transfusion 2016; 56: 2303-2307.
El-Beshlawy A, Salama AA, El-Masry MR, et al. A study of red blood cell alloimmunization and autoimmunization among 200 multitransfused Egyptian β thalassemia patients. Scientific Reports 2020; 10: 1-8.
Saied DA, Kaddah AM, Eldin RMB, et al. Alloimmunization and erythrocyte autoimmunization in transfusion-dependent Egyptian thalassemic patients. Journal of pediatric hematology/oncology 2011; 33: 409-414.
Fucharoen S and Weatherall DJ. Progress toward the control and management of the thalassemias. Hematology/oncology Clinics 2016; 30: 359-371.
Weatherall D. The thalassemias: the role of molecular genetics in an evolving global health problem. The American Journal of Human Genetics 2004; 74: 385-392.
Shah FT, Sayani F, Trompeter S, et al. Challenges of blood transfusions in β-thalassemia. Blood reviews 2019; 37: 100588.
Xu L-H, Fang J-P, Weng W-J, et al. Autoimmune hemolytic anemia in patients with β-thalassemia major. Pediatric Hematology and Oncology 2012; 29: 235-240.
Aygun B, Padmanabhan S, Paley C, et al. Clinical significance of RBC alloantibodies and autoantibodies in sickle cell patients who received transfusions. Transfusion 2002; 42: 37-43.
Motta I, Giannotta J, Ferraresi M, et al. Autoimmune Hemolytic Anemia as a Complication of Congenital Anemias. A Case Series and Review of the Literature. Journal of Clinical Medicine 2021; 10: 3439.
Abdulqader AMR, Mohammed AI and Mohammed NI. Red cell alloimmunization and autoimmunization in multi-transfused thalassemia patients in Sulaymaniyah Province-Iraq. Korean Journal of Clinical Laboratory Science 2020; 52: 98-104.
Al‐Riyami AZ, Al‐Muqbali A, Al‐Sudiri S, et al. Risks of red blood cell alloimmunization in transfusion‐dependent β‐thalassemia in Oman: a 25‐year experience of a university tertiary care reference center and a literature review. Transfusion 2018; 58: 871-878.
Waheed U, Arshad M, Saeed M, et al. Spectrum of alloimmunization among multitransfused beta-thalassemia major patients. Global Journal of Transfusion Medicine 2019; 4: 39.
Thompson AA, Cunningham MJ, Singer ST, et al. Red cell alloimmunization in a diverse population of transfused patients with thalassaemia. British journal of haematology 2011; 153: 121-128.
Perwitasari E, Dalimoenthe NZ, Lismayanti L, et al. Alloantibody Screening on Transfusion Dependent Thalassemia Patients in Dr. Hasan Sadikin General Hospital, Bandung. JOURNAL OF THE INDONESIAN MEDICAL ASSOCIATION Majalah Kedokteran Indonesia 2017; 67.
Alwarawrah Y, Kiernan K and MacIver NJ. Changes in nutritional status impact immune cell metabolism and function. Frontiers in immunology 2018; 9: 1055.
Jansuwan S, Tangvarasittichai O and Tangvarasittichai S. Alloimmunization to red cells and the association of alloantibodies formation with splenectomy among transfusion-dependent β-thalassemia major/HbE patients. Indian Journal of Clinical Biochemistry 2015; 30: 198-203.
Barcellini W, Fattizzo B and Zaninoni A. Management of refractory autoimmune hemolytic anemia after allogeneic hematopoietic stem cell transplantation: current perspectives. Journal of blood medicine 2019; 10: 265.
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.
