Ambient artificial intelligence in smart healthcare systems: Architecture, applications, challenges, and future directions
Keywords:
ambient artificial intelligence, smart health, ambient intelligence, internet of medical things, smart healthcare systems, clinical decision supportAbstract
Smart Health represents the convergence of digital technologies, intelligent systems, and connected healthcare environments to improve the quality, efficiency, and accessibility of healthcare services. Ambient Artificial Intelligence (Ambient AI) has emerged as a core enabler of Smart Health by embedding context-aware, adaptive, and unobtrusive intelligence into clinical and non-clinical healthcare settings. Ambient AI systems continuously sense, analyze, and respond to multimodal data from patients, clinicians, and environments without interrupting routine workflows. This review presents a comprehensive and structured analysis of Ambient AI in Smart Healthcare Systems, focusing on conceptual foundations, system architectures, enabling technologies, and real-world applications. Key use cases include ambient clinical documentation, smart hospitals, continuous patient monitoring, telehealth, and assisted living. The review further discusses the benefits of Ambient AI in enhancing clinical efficiency, patient safety, and personalized care, while critically examining challenges related to data privacy, interoperability, algorithmic bias, ethical considerations, and regulatory compliance. Finally, future research directions are outlined to support the scalable, trustworthy, and equitable deployment of Ambient AI as a foundational component of next-generation Smart Health ecosystems. This review is intended to provide researchers, practitioners, and policymakers with a consolidated understanding of Ambient AI and its role in advancing smart and sustainable healthcare systems.
Downloads
References
Ahmed, H., Al-Suhail, G., & Abood, A. (2025). Next-Generation of Smart Healthcare: A Review of Emerging AI Technologies and Their Clinical Applications. International Journal of Mechatronics, Robotics, and Artificial Intelligence, 1(2), 94-103. DOI: https://doi.org/10.33971/ijmrai.1.2.12
Alamri, M., Haseeb, K., Humayun, M., & Alshammeri, M. (2025). AI-embedded IoT healthcare optimization with trust-aware mobile edge computing: M. Alamri et al. Scientific Reports. DOI: https://doi.org/10.1038/s41598-025-29370-y
Bhambri, P., Soni, R., & Tran, T. A. (Eds.). (2024). Smart healthcare systems: AI and IoT perspectives. CRC Press. DOI: https://doi.org/10.1201/9781032698519
Camacho, D., & Novais, P. (2017). Innovations and practical applications of intelligent systems in ambient intelligence and humanized computing. Journal of Ambient Intelligence and Humanized Computing, 8(2), 155-156. DOI: https://doi.org/10.1007/s12652-017-0454-z
Chakraborty, C., Bhattacharya, M., & Islam, M. A. (2026). Ambient Artificial Intelligence (Ambient AI) undergoes clinical trial evaluation for clinical practice applications. International Journal of Surgery, 10-1097. DOI: https://doi.org/10.1097/JS9.0000000000004894
Dutta, S. (2025). AI and IoT-based smart healthcare solutions in urban areas. Trends in Health Informatics, 2(1), 18-26.
Esmaeili, M., & Toghraee, M. (2025). IoT Requirements for Smart Healthcare Systems Using Ambient Intelligence.
Fogel, A. L., & Kvedar, J. C. (2018). Artificial intelligence powers digital medicine. NPJ digital medicine, 1(1), 5. DOI: https://doi.org/10.1038/s41746-017-0012-2
Gabrielli, D., Prenkaj, B., Velardi, P., & Faralli, S. (2025, November). AI on the Pulse: Real-Time Health Anomaly Detection with Wearable and Ambient Intelligence. In Proceedings of the 34th ACM International Conference on Information and Knowledge Management (pp. 4717-4721). DOI: https://doi.org/10.1145/3746252.3760799
Islam, S. R., Kwak, D., Kabir, M. H., Hossain, M., & Kwak, K. S. (2015). The internet of things for health care: a comprehensive survey. IEEE access, 3, 678-708. DOI: https://doi.org/10.1109/ACCESS.2015.2437951
Khatun, M. A., Memon, S. F., Eising, C., & Dhirani, L. L. (2023). Machine learning for healthcare-IoT security: A review and risk mitigation. IEEE access, 11, 145869-145896. DOI: https://doi.org/10.1109/ACCESS.2023.3346320
Naghib, A., Gharehchopogh, F. S., & Zamanifar, A. (2025). A comprehensive and systematic literature review on intrusion detection systems in the internet of medical things: current status, challenges, and opportunities. Artificial Intelligence Review, 58(4), 114. DOI: https://doi.org/10.1007/s10462-024-11101-w
Panayides, A. S., Amini, A., Filipovic, N. D., Sharma, A., Tsaftaris, S. A., Young, A., ... & Pattichis, C. S. (2020). AI in medical imaging informatics: current challenges and future directions. IEEE journal of biomedical and health informatics, 24(7), 1837-1857. DOI: https://doi.org/10.1109/JBHI.2020.2991043
Park, Y., & Han, J. (2025). Smart home advancements for health care and beyond: systematic review of two decades of user-centric innovation. Journal of Medical Internet Research, 27, e62793. DOI: https://doi.org/10.2196/62793
Roy, T., & Nahid, M. M. (2022, March). The iomt and cloud in healthcare: Use, impact and efficiency of contemporary sensor devices used by patients and clinicians. In Proceedings of the 2nd International Conference on Computing Advancements (pp. 426-434). DOI: https://doi.org/10.1145/3542954.3543015
Sarkar, M., Lee, T. H., & Sahoo, P. K. (2024). Smart healthcare: exploring the internet of medical things with ambient intelligence. Electronics, 13(12), 2309. DOI: https://doi.org/10.3390/electronics13122309
Shaik, T., Tao, X., Higgins, N., Li, L., Gururajan, R., Zhou, X., & Acharya, U. R. (2023). Remote patient monitoring using artificial intelligence: Current state, applications, and challenges. Wiley Interdisciplinary Reviews: Data Mining and Knowledge Discovery, 13(2), e1485. DOI: https://doi.org/10.1002/widm.1485
Shumba, A. T., Montanaro, T., Sergi, I., Fachechi, L., De Vittorio, M., & Patrono, L. (2022). Leveraging IoT-aware technologies and AI techniques for real-time critical healthcare applications. Sensors, 22(19), 7675. DOI: https://doi.org/10.3390/s22197675
Solaiman, E., & Awad, C. (2025). Trust and Dependability in Blockchain & AI Based MedIoT Applications: Research Challenges and Future Directions. arXiv preprint arXiv:2501.02647.
Topol, E. J. (2019). High-performance medicine: the convergence of human and artificial intelligence. Nature medicine, 25(1), 44-56. DOI: https://doi.org/10.1038/s41591-018-0300-7
Published
How to Cite
Issue
Section
Copyright (c) 2026 International journal of health sciences

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.








