Lipid profile in obese children with and without insulin resistance

  • Novita Tjiang Department of Pediatrics, Medical Faculty, Udayana University
  • I Gusti Lanang Sidiartha Department of Pediatrics, Medical Faculty, Udayana University
Keywords: Lipid, Obese, Children, Insulin resistance, Obesity


Obesity is increasing nowadays including in children and there is lack of information on the pathophysiology and their complication such as insulin resistance and dyslipidemia. This study was aimed to investigate the comparison of lipid profile in obese children with and without insulin resistance. A crossectional study held at an elementary school in Denpasar, Bali from August until September 2015. Independent t-test, Mann-Whitney test, and Multivariate analysis of covariance (MANCOVA) were performed to compare lipid profile in obese children with and without insulin resistance. A P-value less than 0.05 was considered statistically significant. A total of 50 obese children were analyzed. In this study, we found 12 subjects (24%) with insulin resistance. Nonsignificant associations were found between insulin resistance with total cholesterol, HDL, LDL, and ratio of HDL/LDL. A significant association was found between insulin resistance and triglyceride level after adjusted age and sex. There was a significant mean difference of triglycerides in the insulin resistance and noninsulin resistance groups in obese children.


Agarwal, R., Jain, P., Ghosh, M. S., & Parihar, K. S. (2017). Importance of Primary Health Care in the Society. International Journal of Health Sciences (IJHS), 1(1), 6-11.

Arslan, N., Erdur, B., & Aydin, A. (2010). Hormones and cytokines in childhood obesity. Indian pediatrics, 47(10), 829-839.

Bastard, J. P., Maachi, M., Lagathu, C., Kim, M. J., Caron, M., Vidal, H., ... & Feve, B. (2006). Recent advances in the relationship between obesity, inflammation, and insulin resistance. European cytokine network, 17(1), 4-12.

Billaiya, R., Jain, A., Agarwal, R., & Jain, P. (2017). Introduction about Child Health Status in India. International Journal of Health Sciences (IJHS), 1(1), 12-22.

Birch, L. L., & Fisher, J. O. (1998). Development of eating behaviors among children and adolescents. Pediatrics, 101(Supplement 2), 539-549.

Burrows, R., Correa-Burrows, P., Reyes, M., Blanco, E., Albala, C., & Gahagan, S. (2015). Healthy Chilean adolescents with HOMA-IR? 2.6 have increased cardiometabolic risk: association with genetic, biological, and environmental factors. Journal of diabetes research, 2015.

Chiarelli, F., & Marcovecchio, M. L. (2008). Insulin resistance and obesity in childhood. European Journal of Endocrinology, 159(suppl 1), S67-S74.

Cruz, M. L., & Goran, M. I. (2004). The metabolic syndrome in children and adolescents. Current diabetes reports, 4(1), 53-62.

Dewi, M. R., & Sidiartha, G. L. (2013). Prevalensi dan faktor risiko obesitas anak sekolah dasar di daerah urban dan rural. Medicina, 44(1).

Gahagan, S. (2011). Overweight and obesity. Kliegman RM, Stanton BF, Behrman RE, Geme JWS, Schor NF. Nelson textbook of pediatrics. 19th ed. Philadelphia: Elsevier/Saunders, 179-188.

García, O. P. (2012). Effect of vitamin A deficiency on the immune response in obesity. Proceedings of the Nutrition Society, 71(2), 290-297.

Kesehatan, D., & RI, K. K. (2013). Riset kesehatan dasar. Jakarta: Badan Penelitian dan Pengembangan Kesehatan Departemen Kesehatan Republik Indonesia.

Keskin, M., Kurtoglu, S., Kendirci, M., Atabek, M. E., & Yazici, C. (2005). Homeostasis model assessment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents. Pediatrics, 115(4), e500-e503.

Klop, B., Elte, J. W. F., & Cabezas, M. C. (2013). Dyslipidemia in obesity: mechanisms and potential targets. Nutrients, 5(4), 1218-1240.

Lee, J. M., Okumura, M. J., Davis, M. M., Herman, W. H., & Gurney, J. G. (2006). Prevalence and determinants of insulin resistance among US adolescents: a population-based study. Diabetes care, 29(11), 2427-2432.

López-Alarcón, M., Perichart-Perera, O., Flores-Huerta, S., Inda-Icaza, P., Rodríguez-Cruz, M., Armenta-Álvarez, A., ... & Mayorga-Ochoa, M. (2014). Excessive refined carbohydrates and scarce micronutrients intakes increase inflammatory mediators and insulin resistance in prepubertal and pubertal obese children independently of obesity. Mediators of inflammation, 2014.

Malaiya, S., Shrivastava, A., Prasad, G., & Jain, P. (2017). Impact of Medical Education Trend in Community Development. International Journal of Health Sciences (IJHS), 1(1), 23-27.

Moran, A., Jacobs, D. R., Steinberger, J., Steffen, L. M., Pankow, J. S., Hong, C. P., & Sinaiko, A. R. (2008). Changes in insulin resistance and cardiovascular risk during adolescence: establishment of differential risk in males and females. Circulation, 117(18), 2361-2368.

Ng, M., Fleming, T., Robinson, M., Thomson, B., Graetz, N., Margono, C., ... & Abraham, J. P. (2014). Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. The lancet, 384(9945), 766-781.

Nicklas, T. A., Baranowski, T., Cullen, K. W., & Berenson, G. (2001). Eating patterns, dietary quality and obesity. Journal of the American College of Nutrition, 20(6), 599-608.

O'Connor, T. M., Yang, S. J., & Nicklas, T. A. (2006). Beverage intake among preschool children and its effect on weight status. Pediatrics, 118(4), e1010-e1018.

Ogden, C. L., Carroll, M. D., Kit, B. K., & Flegal, K. M. (2014). Prevalence of childhood and adult obesity in the United States, 2011-2012. Jama, 311(8), 806-814.

Pastucha, D., Filipcikova, R., Horáková, D., Radová, L., Marinov, Z., Malincikova, J., ... & Dobiás, M. (2013). The incidence of metabolic syndrome in obese Czech children: the importance of early detection of insulin resistance using homeostatic indexes HOMA-IR and QUICKI. Physiological research, 62(3), 277.

Robins, S. J., Lyass, A., Zachariah, J. P., Massaro, J. M., & Vasan, R. S. (2011). Insulin resistance and the relationship of a dyslipidemia to coronary heart disease: the Framingham Heart Study. Arteriosclerosis, thrombosis, and vascular biology, 31(5), 1208-1214.

Saad, M. J., Araki, E., Miralpeix, M., Rothenberg, P. L., White, M. F., & Kahn, C. R. (1992). Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance. The Journal of clinical investigation, 90(5), 1839-1849.

Singh, Y., Garg, M. K., Tandon, N., & Marwaha, R. K. (2013). A study of insulin resistance by HOMA-IR and its cut-off value to identify metabolic syndrome in urban Indian adolescents. Journal of clinical research in pediatric endocrinology, 5(4), 245.

Slyper, A. H. (2004). The pediatric obesity epidemic: causes and controversies. The Journal of Clinical Endocrinology & Metabolism, 89(6), 2540-2547.

Steinberger, J., & Daniels, S. R. (2003). Obesity, insulin resistance, diabetes, and cardiovascular risk in children: an American Heart Association scientific statement from the Atherosclerosis, Hypertension, and Obesity in the Young Committee (Council on Cardiovascular Disease in the Young) and the Diabetes Committee (Council on Nutrition, Physical Activity, and Metabolism). Circulation, 107(10), 1448-1453.

Ten, S., & Maclaren, N. (2004). Insulin resistance syndrome in children. The Journal of Clinical Endocrinology & Metabolism, 89(6), 2526-2539.

View in (Google Scholar)

Viner, R. M., Segal, T. Y., Lichtarowicz-Krynska, E., & Hindmarsh, P. (2005). Prevalence of the insulin resistance syndrome in obesity. Archives of Disease in Childhood, 90(1), 10-14.

Williams, J., Scarborough, P., Matthews, A., Cowburn, G., Foster, C., Roberts, N., & Rayner, M. (2014). A systematic review of the influence of the retail food environment around schools on obesity?related outcomes. Obesity reviews, 15(5), 359-374.

Yin, J., Li, M., Xu, L., Wang, Y., Cheng, H., Zhao, X., & Mi, J. (2013). Insulin resistance determined by Homeostasis Model Assessment (HOMA) and associations with metabolic syndrome among Chinese children and teenagers. Diabetology & metabolic syndrome, 5(1), 71.

Yussac, M. A. A., Cahyadi, A., Putri, A. C., Dewi, A. S., Khomaini, A., Bardosono, S., & Suarthana, E. (2007). Prevalensi obesitas pada anak usia 4-6 tahun dan hubungannya dengan asupan serta pola makan. Majalah Kedokteran Indonesia, 57(2), 47-53.

How to Cite
Tjiang, N., & Sidiartha, I. G. L. (2018). Lipid profile in obese children with and without insulin resistance. International Journal of Health Sciences, 2(2), 9-17.