SU-6656 attenuates alcohol dependence induced withdrawal syndrome in mice
Keywords:
src kinase, SU-6656, withdrawal severity score, locomotor activity, PTZ kindling seizures, force swim test, anxietyAbstract
Upregulation of Src kinase plays a important role in alcohol addiction, so pharmacological modulation of Src kinase with SU6656 a selective inhibitor, may play a prominent in pharmacotherapy in alcohol dependence induced withdrawal syndrome. Experimental approach: Administration of Alcohol (2 g/kg, 10%, v/v, oral), once daily for 7 days. Assessment of behavioral parameters and exploratory parameters was done on 7 day after 8 hr. of the last ethanol administration for a period of 120 minutes. Various behavioural parameters were conducted like wall climbing test, composite withdrawal severity score, anxiety like behaviour assessed in open field and elevated plus test. Treatment with SU-6656 (1, 5 & 10 mg/kg, i.p.) markedly and dose dependently (p<0.05) attenuated spontaneous alcohol withdrawal syndrome in mice measured in terms of withdrawal severity score, wall climbing, locomotor sensitization by open field test and anxiety. Thus, it is suggested that activation of Src kinase pathway is involved in the development of alcohol dependence induced withdrawal syndrome. Modulation of src kinase may be used as therapeutic agent to overcome the problems related with alcohol dependence.
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Anton, R.F., Latham, P., Voronin, K., Book, S., Hoffman, M., Prisciandaro, J., & Bristol, E. (2020). Efficacy of Gabapentin for the Treatment of Alcohol Use Disorder in Patients With Alcohol Withdrawal Symptoms: A Randomized Clinical Trial. JAMA internal medicine, 180(5),728-736. https://doi.org/10.1001/jamainternmed.2020.0249
Assis, V.O., Gonzaga, N.A., Silva, C.B.P., Pereira, L.C., Padovan, C.M., & Tirapelli, C.R. (2020). Ethanol Withdrawal Alters the Oxidative State of the Heart Through AT1-Dependent Mechanisms. Alcohol, 55(1),3-10. https://doi.org/10.1093/alcalc/agz101
Barry, S.M., & McGinty, J.F. (2017). Role of Src family kinases in BDNF-mediated suppression of cocaine-seeking and prevention of cocaine-induced ERK, GluN2A, and GluN2B dephosphorylation in the prelimbic cortex. Neuropsychopharmacology, 42(10), 1972-80. https://doi.org/10.1038/npp.2017.114
Barua, C.C., Talukdar, A., Begum, S.A., Borah, P., & Lahkar, M. (2012). Anxiolytic activity of methanol leaf extract of Achyranthes aspera Linn in mice using experimental models of anxiety. Indian Journal of Pharmacology, 44,63-7. https://doi.org/10.4103/0253-7613.91869
Blake, R.A., Broome, M.A., Liu, X., Wu, J., Gishizky, M., Sun, L., & Courtneidge, S.A. (2000). SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling. Molecular and cellular biology, 20(23),9018-27. https://doi.org/10.1128/mcb.20.23.9018-9027.2000
Bornebusch, A.B., Mason, G.F., Tonetto, S., Damsgaard, J., Gjedde, A., Fink-Jensen, A., & Thomsen, M. (2021). Effects of ketogenic diet and ketone monoester supplement on acute alcohol withdrawal symptoms in male mice. Psychopharmacology (Berl), 238(3),833-844. https://doi.org/10.1007/s00213-020-05735-1
Bravo, I.M., Luster, B.R., Flanigan, M.E., Perez, P.J., Cogan, E.S., Schmidt, K.T., & McElligott, Z.A. (2020). Divergent behavioral responses in protracted opioid withdrawal in male and female C57BL/6J mice. European Journal of Neuroscience, 51(3),742-754. https://doi.org/10.1111/ejn.14580
Choi, H.Y., Seo, J.S., & Lee, S.K. (2020). Assessment and Treatment of Alcohol Withdrawal Syndrome. Korean Journal of Gastroenterology, 76(2),71-77. https://doi.org/10.4166/kjg.2020.76.2.71
El Mostafi, H., Elhessni, A., Touil, T., Ouichou, A., Laaziz, A., Doumar, H.,& Mesfioui, A. (2020). Argan oil supplementation attenuates voluntary ethanol consumption and withdrawal syndrome promoted by adolescent intermittent ethanol in rat. Alcohol, 87,39-50. https://doi.org/10.1016/j.alcohol.2020.04.007
Estevez, G. A., Espinosa, A. H. R., & Rodríguez, D. L. (2019). Design of intervention program for preventing of alcohol misuse in university students. International Journal of Health & Medical Sciences, 2(1), 33-38. https://doi.org/10.31295/ijhms.v2n1.86
Feng, J., Zhang, X., Shan, C., Xia, J., Zhang, Z., Shi, H., Leng, K., Wu, Y., Ji, C., & Zhong, T. (2021). Src family kinases involved in the differentiation of human preadipocytes. Molecular and Cellular Endocrinology, 533,111323. https://doi.org/10.1016/j.mce.2021.111323
Fowler, A.J., Hebron, M., Missner, A.A., Wang. R., Gao, X., Kurd-Misto, B.T., Liu, X., & Moussa, C.E. (2019). Multikinase ABL/DDR/SRC inhibition produces optimal effects for tyrosine kinase inhibition in neurodegeneration. Drugs in R&D, 19(2),149-66. https://doi.org/10.1007/s40268-019-0266-z
Gupta, A., Khan, H., Kaur, A., & Singh, T.G. (2021). Novel Targets Explored in Treatment of Alcohol Dependence induced Withdrawal Syndrome. CNS & Neurological Disorders Drug Targets, 20(2),158-173. https://doi.org/10.2174/1871527319999201118155721
Hansen, A.W., Almeida, F.B., Bandiera, S., Pulcinelli, R.R., Caletti, G., Agnes, G., de Paula, L.F., Nietiedt, N.A., Nin, M.S., Barros, H.M., & Gomez, R. (2020). Correlations between subunits of GABAA and NMDA receptors after chronic alcohol treatment or withdrawal, and the effect of taurine in the hippocampus of rats. Alcohol, 82,63-70. https://doi.org/10.1016/j.alcohol.2019.08.005
Heilig, M., & Koob, G.F. (2007). A key role for corticotropin-releasing factor in alcohol dependence. Trends in Neurosciences, 30(8),399-406. https://doi.org/10.1016/j.tins.2007.06.006
Jury, N.J., Radke, A.K., Pati, D., Kocharian, A., Mishina, M., Kash, T.L, & Holmes, A. (2018). NMDA receptor GluN2A subunit deletion protects against dependence-like ethanol drinking. Behavioural brain research, 353, 124-8. https://doi.org/10.1016/j.bbr.2018.06.029
Karadayian, A.G., Busso, M.J., Feleder, C., & Cutrera, R.A. (2013). Alterations in affective behavior during the time course of alcohol hangover. Behavioural Brain Research, 15, 253,128-38. https://doi.org/10.1016/j.bbr.2013.07.011
Keil, M.F., Briassoulis, G., & Stratakis, C.A. (2016). The role of protein kinase A in anxiety behaviors. Neuroendocrinology, 103(6),625-39. https://doi.org/10.1159/000444880
Khom, S., Wolfe, S.A., Patel, R.R., Kirson, D., Hedges, D.M., Varodayan, F.P., Bajo, M., & Roberto, M. (2020). Alcohol Dependence and Withdrawal Impair Serotonergic Regulation of GABA Transmission in the Rat Central Nucleus of the Amygdala. Journal of Neuroscience, 40(36),6842-6853. https://doi.org/10.1523/jneurosci.0733-20.2020
Luster, B.R., Cogan, E.S., Schmidt, K.T., Pati, D., Pina, M.M., Dange, K., & McElligott, Z.A. (2020). Inhibitory transmission in the bed nucleus of the stria terminalis in male and female mice following morphine withdrawal. Addiction Biology, 25(3),e12748. https://doi.org/10.1111/adb.12748
Navarro, J.F., Burón, E., & Martín-López, M. (2006). Anxiolytic-like activity of SB-205384 in the elevated plus-maze test in mice. Psicothema, 18(1), 100-4.
Nie, L., Ye, W.R., Chen, S., Chirchiglia, D., & Wang, M. (2021). Src Family Kinases in the Central Nervous System: Their Emerging Role in Pathophysiology of Migraine and Neuropathic Pain. Current Neuropharmacology, 19(5),665-678. https://doi.org/10.2174/1570159x18666200814180218
Rehni, A.K., & Singh, T.G. (2013). Pharmacological modulation of geranylgeranyltransferase and farnesyltransferase attenuates opioid withdrawal in vivo and in vitro. Neuropharmacology, 71,19-26. https://doi.org/10.1016/j.neuropharm.2013.01.022
Rehni, A.K., Bhateja, P., Singh, T.G, & Singh, N. (2008). Nuclear factor-κ-B inhibitor modulates the development of opioid dependence in a mouse model of naloxone-induced opioid withdrawal syndrome. Behavioural pharmacology, 19(3),265-269. https://doi.org/10.1097/fbp.0b013e3282febcd9
Rehni, A.K., Singh, T.G., & Arora, S. (2011). SU-6656, a selective Src kinase inhibitor, attenuates mecamylamine-precipitated nicotine withdrawal syndrome in mice. Nicotine & tobacco research, 14(4),407-14. https://doi.org/10.1093/ntr/ntr228
Rehni, A.K., Singh, T.G., & Arora, S. (2011). SU-6656, a selective Src kinase inhibitor, attenuates mecamylamine-precipitated nicotine withdrawal syndrome in mice. Nicotine & Tobacco Research, 14(4),407-414. https://doi.org/10.1093/ntr/ntr228
Roberto, M., Kirson, D., & Khom, S. (2021). The Role of the Central Amygdala in Alcohol Dependence. Cold Spring Harbor perspectives in medicine, 11(2),a039339. https://doi.org/10.1101/cshperspect.a039339
Sgobbi, R.F., & Nobre, M.J. (2020). Differential effects of early exposure to alcohol on alcohol preference and blood alcohol levels in low- and high-anxious rats. Experimental Brain Research, 238(12),2753-2768. https://doi.org/10.1007/s00221-020-05932-6
Sharma, R., Sharma, A., Sahota, P., & Thakkar, M.M. (2020). Orexin gene expression is downregulated in alcohol dependent rats during acute alcohol withdrawal. Neuroscience Letters, 739,135347. https://doi.org/10.1016/j.neulet.2020.135347
Singh, S., Singh, T.G., Dhiman, S., Satija, S., & Gupta, S. (2020). Pharmacological Evaluation of Tinospora Cordifolia On Nicotine Dependence In Mice. Plant Archives, 20(1),3757-3762.
Singh, T.G., Rehni, A.K., & Arora, S. (2013). Ro 32-0432 attenuates mecamylamine-precipitated nicotine withdrawal syndrome in mice. Naunyn-Schmiedeberg's archives of pharmacology, 386(3),197-204. https://doi.org/10.1007/s00210-012-0825-0
Singh, T.G., Rehni, A.K., & Arora, S.K. (2013). Pharmacological modulation of farnesyltransferase subtype I attenuates mecamylamine-precipitated nicotine withdrawal syndrome in mice. Behavioural pharmacology, 24(8),668-677. https://doi.org/10.1097/fbp.0000000000000009
Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Get vaccinated when it is your turn and follow the local guidelines. International Journal of Health Sciences, 5(3), x-xv. https://doi.org/10.53730/ijhs.v5n3.2938
Wang, D., Enck, J., Howell, B.W., & Olson, E.C. (2019). Ethanol Exposure Transiently Elevates but Persistently Inhibits Tyrosine Kinase Activity and Impairs the Growth of the Nascent Apical Dendrite. Molecular Neurobiology, 56(8),5749-5762. https://doi.org/10.1007/s12035-019-1473-x
Wang, J., Carnicella, S., Phamluong, K., Jeanblanc, J., Ronesi, J.A., Chaudhri, N., Janak, P.H., Lovinger, D.M., & Ron, D. (2007). Ethanol induces long-term facilitation of NR2B-NMDA receptor activity in the dorsal striatum: implications for alcohol drinking behavior. Journal of Neuroscience, 27(13),3593-602. https://doi.org/10.1523/jneurosci.4749-06.2007
Xie, X., Arguello, A.A., Wells, A.M., Reittinger, A.M., & Fuchs, R.A. (2013). Role of a hippocampal SRC-family kinase-mediated glutamatergic mechanism in drug context-induced cocaine seeking. Neuropsychopharmacology, 38(13),2657-65. https://doi.org/10.1038/npp.2013.175
Zhang, L., Kibaly, C., Wang, Y.J., Xu, C., Song, K.Y., McGarrah, P.W., Loh, H.H., Liu, J.G., & Law, P.Y. (2017). Src‐dependent phosphorylation of μ‐opioid receptor at Tyr336 modulates opiate withdrawal. EMBO molecular medicine, 9(11),1521-36. https://doi.org/10.15252/emmm.201607324
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