The use of nanoparticle form of milled teeth as a bone graft substitute in rabbits
Keywords:
bone substitutes, milled teeth, nanoparticleAbstract
Aims of the study: This study was designed to determine the effects of milled tooth in its nanoparticle forms as a bone substitute materials on the acceleration of bone healing in rabbits. Materials and Methods: Sixteen albino rabbits were used in the experiment that were divided into two groups: nanoparticle group (M0 group) and control group. Rabbits were anesthetized using intramuscularly administered 10% ketamine (40mgkg) and 2% xylazine (5mgkg) (Inferchemi, Holland). After shaving and sterilization of the site of the operation, a 2cm submandibular incision was done. Then 3 millimeter circular anterior full-thickness defect was created near the midline of the mandible. The anterior defect was filled with 50-100nm milled tooth material nanoparticles. The incision was sutured with 3/0 black silk. Following surgery, each rabbit was given 30 mg/kg oxytetracycline intramuscularly. The rabbits were euthanized at 3, 7, 14, and 28 days afterwards. Then the specimens were dried and fixed in paraffin before being removed from the skulls. Histological examination the specimens was done.
Downloads
References
Billow, Damien et al. “The Reamer-Irrigator-Aspirator System: A Review.” Surgical technology international vol. 29 (2016): 287-294.
Goulet, Jennifer L., et al. "Deficiency of 5-lipoxygenase accelerates renal allograft rejection in mice." The Journal of Immunology 167.11 (2001): 6631-6636.
Greenwald, A. Seth, et al. "Bone-graft substitutes: facts, fictions, and applications." Jbjs 83.2 (2001): S98-103.
Baldwin, Paul, et al. "Autograft, allograft, and bone graft substitutes: clinical evidence and indications for use in the setting of orthopaedic trauma surgery." Journal of orthopaedic trauma 33.4 (2019): 203-213.
Pollock, Raymond, et al. "Donor site morbidity following iliac crest bone harvesting for cervical fusion: a comparison between minimally invasive and open techniques." European Spine Journal 17.6 (2008): 845-852.
D’Souza, Marissa, et al. "Graft materials and biologics for spinal interbody fusion." Biomedicines 7.4 (2019): 75.
Rasouli, Rahimeh, Ahmed Barhoum, and Hasan Uludag. "A review of nanostructured surfaces and materials for dental implants: surface coating, patterning and functionalization for improved performance." Biomaterials science 6.6 (2018): 1312-1338.
McINTYRE, ROBIN A. "Common nano-materials and their use in real world applications." Science progress 95.1 (2012): 1-22.
Priyadarsini, Subhashree, Sumit Mukherjee, and Monalisa Mishra. "Nanoparticles used in dentistry: A review." Journal of oral biology and craniofacial research 8.1 (2018): 58-67.
Fillingham, Y., and J. Jacobs. "Bone grafts and their substitutes." The bone & joint journal 98.1_Supple_A (2016): 6-9.
Fernandez de Grado, Gabriel, et al. "Bone substitutes: a review of their characteristics, clinical use, and perspectives for large bone defects management." Journal of tissue engineering 9 (2018): 2041731418776819.
Wang, Wenhao, and Kelvin WK Yeung. "Bone grafts and biomaterials substitutes for bone defect repair: A review." Bioactive materials 2.4 (2017): 224-247.
Kim, Soo Min, et al. "The effect of copper pre-cleaning on graphene synthesis." Nanotechnology 24.36 (2013): 365602.
Sheikh, Zeeshan, et al. "Biodegradable materials for bone repair and tissue engineering applications." Materials 8.9 (2015): 5744-5794.
Fitra, Legowo, D., Utomo, B., Suroto, N. S., Parenrengi, M. A., & Al-Fauzi, A. (2021). Intracranial foreign body granuloma caused by oxidized cellulose polymer and etherified sodium carboxymethyl cellulose: an experimental study with orictolagus cuniculus rabbits. International Journal of Health & Medical Sciences, 4(2), 267-272. https://doi.org/10.31295/ijhms.v4n2.1741
Del Canto-Díaz A, de Elío-Oliveros J, Del Canto-Díaz M, Alobera-Gracia MA, Del Canto-Pingarrón M, Martínez-González JM. Use of autologous tooth-derived graft material in the post-extraction dental socket. Pilot study. Med Oral Patol Oral Cir Bucal. 2019;24(1):e53-e60.
Sohn, Hoon-Sang, and Jong-Keon Oh. "Review of bone graft and bone substitutes with an emphasis on fracture surgeries." Biomaterials research 23.1 (2019): 1-7.
Burdușel, Alexandra-Cristina, et al. "Inorganic Nanoparticles in Bone Healing Applications." Pharmaceutics 14.4 (2022): 770.
Rejab, Atalla F. "The effects of two bone substitute materials in the treatment of experimentally induced mandibular defects: An experimental study." Al-Rafidain Dental Journal 18.1 (2018): 9-20.
Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Health and treatment of diabetes mellitus. International Journal of Health Sciences, 5(1), i-v. https://doi.org/10.53730/ijhs.v5n1.2864
Aroni, Maurício Andrés Tinajero, et al. "Loading deproteinized bovine bone with strontium enhances bone regeneration in rat calvarial critical size defects." Clinical oral investigations 23.4 (2019): 1605-1614.
Stavropoulos, Andreas, et al. "Clinical and histologic evaluation of granular Beta‐tricalcium phosphate for the treatment of human intrabony periodontal defects: a report on five cases." Journal of periodontology 81.2 (2010): 325-334.
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.
