Biobanking and its role in clinical research and pathology
Keywords:
Biobanks, precision medicine, clinical research, virtual biobanks, molecular pathology, ethical considerationsAbstract
Background: Biobanks have gained recognition for their crucial role in clinical research and pathology, particularly in advancing precision medicine. Their evolution from traditional to virtual biobanks marks a significant shift in biomedical research methodology. Aim: This article examines the development, significance, and operational aspects of biobanks, highlighting their role in personalized medicine and the challenges they face. Methods: A comprehensive review of literature and established guidelines was conducted to analyze the characteristics, classifications, and governance of biobanks, with a focus on their infrastructure and data management. Results: Biobanks, both physical and virtual, provide invaluable resources for molecular and genetic epidemiology, molecular pathology, and pharmacogenomics. They enable researchers to conduct large-scale studies, identify biomarkers, and tailor treatments to individual genetic profiles. However, significant challenges exist, including ethical concerns, funding, and the need for robust governance structures. Conclusion: Biobanks represent a vital component of modern biomedical research, facilitating advances in personalized medicine. While they offer immense potential, addressing infrastructural and ethical challenges is essential for their sustainability and effectiveness in improving health outcomes.
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