Different evaluation parameters of floating microsphere of ofloxacin

G Dhone Pravin; Kavita Kavita; Shende Tanaji; P. N Khandelwal

doi:10.53730/ijhs.v6nS4.9859

Different evaluation parameters of floating microsphere of ofloxacin

https://doi.org/10.53730/ijhs.v6nS4.9859

Authors

Dhone Pravin G Professor & Head, Department of Pharmacology, RSDKS GMC, Ambikapur
Kavita Associate professor Government medical college Mahasamund
Shende Tanaji Associate professor, Department of Pharmacology NKPSIMS Nagpur
Khandelwal P. N Professor Of Pharmacology, MGM Medical College, Kamothe, Navi Mumbai

Keywords:

microsphere, floating tablet, ofloxacin

Abstract

The Floating Microsphere of Ofloxacin requires a novel gastroretentive drug delivery system which can provide an extended period of time in stomach and improve oral bioavailability. Floating microspheres were characterized for floating ability, compatibility study, particle size and shape, entrapment efficiency, in-vitro drug release. Due to their low density, these multi particulate drug delivery systems showed good floating ability and remained in gastric environment for more than 24 hrs, required for sustained therapeutic activity. Major advantages of the system include ease of preparation, good floating ability, high encapsulation efficiency and sustained drug release over 24 hours. From this study, it was concluded that formulation of floating microspheres of ofloxacin offers prolonged gastric residence time and continuous release of the medication over an extended period of time thus oral bioavailability of the drug and subsequent efficacy is improved.

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Published

28-06-2022

How to Cite

Dhone Pravin, G., Kavita, K., Tanaji, S., & Khandelwal, P. N. (2022). Different evaluation parameters of floating microsphere of ofloxacin. International Journal of Health Sciences, 6(S4), 4863–4870. https://doi.org/10.53730/ijhs.v6nS4.9859

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Issue

Vol. 6 No. S4 (2022)

Section

Peer Review Articles

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