Paraquat poisoning
Herbicide with fatal outcome
Keywords:
multiorgan failure, paraquat, decontaminationAbstract
Paraquat (10-dimethyl-4, 40-bipyridylium dichloride) is the most common herbicide used worldwide. Due to its inherent toxicity and lack of effective treatment, it has high case fatality of more than 50%. Paraquat exposure through ingestion or inhalation leads to multi-organ involvement including lungs, CNS, heart, kidneys and liver. Treatment is mainly supportive including initial resuscitation, gastrointestinal decontamination, anti-inflammatory, antioxidant and immunosuppressive therapy. We are reporting two cases of paraquat poisoning and their management in intensive care unit, of which one was successfully treated and discharged from ICU while other one expired.
Downloads
References
Suntres ZE. Role of antioxidants in paraquat toxicity. Toxicology 2002; 180:65-77.
Eddleston M, Phillips MR. Self poisoning with pesticides. BMJ 2004; 328: 42–4
Buckley NA, Karalliedde L, Dawson A, Senanayake N, Eddleston M. Where is the evidence for treatments used in pesticide poisoning? Is clinical toxicology fiddling while the developing world burns? J Toxicol Clin Toxicol 2004; 4:113–6.
Gawarammana IB, Buckley NA. Medical management of paraquat ingestion. Br J Clin Pharmacol. 2011; 72:745-57.
J. S. Sandhu, A. Dhiman, R. Mahajan, and P. Sandhu, “Outcome of paraquat poisoning—a five year study,” Indian Journal of Nephrology 2003; 13:64–8.
Khosya S, Gothwal S. Two cases of paraquat poisoning from kota, rajasthan, India. Case Rep Crit Care. 2012; 2012:652146.
Sawada Y, Yamamoto I, Hirokane T, Nagai Y, Satoh Y, Ueyama M. Severity index of paraquat poisoning. Lancet. 1988; 1:1333.
R. Agarwal, R. Srinivas, A. N. Aggarwal, and D. Gupta, “Experience with paraquat poisoning in a respiratory intensive care unit in North India,” Singapore Medical Journal 2006; 47:1033-7..
Z. E. Suntres, “Role of antioxidants in paraquat toxicity,” Toxicology 2002; 180:65-77.
Elenga N, Merlin C, Le Guern R, Kom-Tchameni R, Ducrot YM, Pradier M et al. Clinical features and prognosis of paraquat poisoning in French Guiana: A review of 62 cases. Medicine (Baltimore). 2018; 97:e9621.
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.
