The prevalence of cardiovascular disease in male patients with type 2 diabetes mellitus and erectile dysfunction, along with an assessment of shared cardiovascular risk factors

CVD prevalence and the risk factors in T2DM males with ED

https://doi.org/10.53730/ijhs.v9n2.15655

Authors

  • Emad Niema Faiha Specialized Diabetes, Endocrine and Metabolism Center (FDEMC), University of Basrah, Iraq
  • Rawayh Albaghlany Department of Medical Microbiology, College of Dentistry, University of Basrah, Iraq. Faiha Specialized Diabetes, Endocrine, and Metabolism Center (FDEMC), University of Basrah Iraq
  • Abas Mansor Faiha Specialized Diabetes, Endocrine and Metabolism Center (FDEMC), University of Basrah, Iraq

Keywords:

cardiovascular disease, diabetes, endothelial dysfunction, erectile dysfunction

Abstract

In men with T2DM, ED is correlated with increased rates of cardiovascular events when compared to men with T2DM who do not experience ED. This association suggests the presence of underlying health issues that require timely intervention. The objective of this study was to examine the cardiovascular risk in men with T2DM and ED. Identifying these risk factors may facilitate preventive measures to improve clinical outcomes in this high-risk population. Participants were categorized into two groups based on their CVD status. A comparative analysis of the two groups was conducted on age, the presence of neuropathy, tobacco usage, and alcohol consumption. CVD was present in 51.6 % of the total sample. In both groups, the mean qualification years, duration of diabetes, BMI, cholesterol levels, prevalence of hypertension, and use of drugs affecting ED were similar. Patients in the CVD group were older, smoked, used alcohol, and had CVD more frequently. In males with T2DM and ED, increased ischemic heart disease, stroke, and peripheral vascular complications were all increased. Our analysis indicates a direct association between ED and CVD in males with T2DM, suggesting a more complex relationship in which ED may function as a contributing indicator of more advanced disease.

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References

Bivalacqua, T. J., Allen, B. K., Brock, G. B., Broderick, G. A., Chou, R., Kohler, T. S., ... & Bennett Jr, N. E. (2022). The diagnosis and management of recurrent ischemic priapism, priapism in sickle cell patients, and non-ischemic priapism: an AUA/SMSNA guideline. Journal of Urology, 208(1), 43-52. DOI: https://doi.org/10.1097/JU.0000000000002767

Blumentals, W. A., Gomez-Caminero, A., Joo, S., & Vannappagari, V. (2004). Should erectile dysfunction be considered as a marker for acute myocardial infarction? Results from a retrospective cohort study. International Journal of Impotence Research, 16(4), 350-353. DOI: https://doi.org/10.1038/sj.ijir.3901174

Bozkurt, B., Aguilar, D., Deswal, A., Dunbar, S. B., Francis, G. S., Horwich, T., ... & Yancy, C. (2016). Contributory risk and management of comorbidities of hypertension, obesity, diabetes mellitus, hyperlipidemia, and metabolic syndrome in chronic heart failure: a scientific statement from the American Heart Association. Circulation, 134(23), e535-e578. DOI: https://doi.org/10.1161/CIR.0000000000000450

Burnett, A. L. (2003). Pathophysiology of priapism: dysregulatory erection physiology thesis. The Journal of urology, 170(1), 26-34. https://doi.org/10.1097/01.ju.0000046303.22757.f2 DOI: https://doi.org/10.1097/01.ju.0000046303.22757.f2

Burnett, A. L. (2006). The role of nitric oxide in erectile dysfunction: implications for medical therapy. The Journal of Clinical Hypertension, 8, 53-62. DOI: https://doi.org/10.1111/j.1524-6175.2006.06026.x

Corona, G., Rastrelli, G., Isidori, A. M., Pivonello, R., Bettocchi, C., Reisman, Y., ... & Maggi, M. (2020). Erectile dysfunction and cardiovascular risk: a review of current findings. Expert review of cardiovascular therapy, 18(3), 155-164. DOI: https://doi.org/10.1080/14779072.2020.1745632

Dilixiati, D., Waili, A., Tuerxunmaimaiti, A., Tao, L., Zebibula, A., & Rexiati, M. (2024). Risk factors for erectile dysfunction in diabetes mellitus: a systematic review and meta-analysis. Frontiers in Endocrinology, 15, 1368079. DOI: https://doi.org/10.3389/fendo.2024.1368079

Eckel, R. H., Bornfeldt, K. E., & Goldberg, I. J. (2021). Cardiovascular disease in diabetes, beyond glucose. Cell metabolism, 33(8), 1519-1545. DOI: https://doi.org/10.1016/j.cmet.2021.07.001

Fakhruddin, S., Alanazi, W., & Jackson, K. E. (2017). Diabetes‐induced reactive oxygen species: mechanism of their generation and role in renal injury. Journal of diabetes research, 2017(1), 8379327. DOI: https://doi.org/10.1155/2017/8379327

Förstermann, U., & Li, H. (2011). Therapeutic effect of enhancing endothelial nitric oxide synthase (eNOS) expression and preventing eNOS uncoupling. British journal of pharmacology, 164(2), 213-223. DOI: https://doi.org/10.1111/j.1476-5381.2010.01196.x

Hamur, H., Duman, H., Keskin, E., Inci, S., Kucuksu, Z., Degirmenci, H., & Topal, E. (2015). The relation between erectile dysfunction and extent of coronary artery disease in the patients with stable coronary artery disease. International journal of clinical and experimental medicine, 8(11), 21295.

Handelsman, D. J., Yeap, B. B., Flicker, L., Martin, S., Wittert, G. A., & Ly, L. P. (2015). Age-specific population centiles for androgen status in men. European journal of endocrinology, 173(6), 809-817. DOI: https://doi.org/10.1530/EJE-15-0380

Hegazy, M. W., Mahmood, R. I., Al Otaibi, M. F., & Khalil, E. M. (2016). Hypofractionated volumetric modulated arc radiotherapy with simultaneous elective nodal irradiation is feasible in prostate cancer patients: a single institution experience. Journal of the Egyptian National Cancer Institute, 28(2), 101-110. https://doi.org/10.1016/j.jnci.2016.04.001 DOI: https://doi.org/10.1016/j.jnci.2016.04.001

Jackson, G., Betteridge, J., Dean, J., Eardley, I., Hall, R., Holdright, D., ... & Sever, P. (2002). A systematic approach to erectile dysfunction in the cardiovascular patient: a Consensus Statement--update 2002. International journal of clinical practice, 56(9), 663-671. DOI: https://doi.org/10.1111/j.1742-1241.2002.tb11349.x

Kessler, A., Sollie, S., Challacombe, B., Briggs, K., & Van Hemelrijck, M. (2019). The global prevalence of erectile dysfunction: a review. BJU international, 124(4), 587-599. DOI: https://doi.org/10.1111/bju.14813

Khanna, N. N., Maindarkar, M., Saxena, A., Ahluwalia, P., Paul, S., Srivastava, S. K., ... & Suri, J. S. (2022). Cardiovascular/stroke risk assessment in patients with erectile dysfunction—a role of carotid wall arterial imaging and plaque tissue characterization using artificial intelligence paradigm: a narrative review. Diagnostics, 12(5), 1249. DOI: https://doi.org/10.3390/diagnostics12051249

Marma, A. K., & Lloyd-Jones, D. M. (2009). Systematic examination of the updated Framingham heart study general cardiovascular risk profile. Circulation, 120(5), 384-390. DOI: https://doi.org/10.1161/CIRCULATIONAHA.108.835470

O'Donnell, A. B., Araujo, A. B., & McKinlay, J. B. (2004). The health of normally aging men: the Massachusetts Male Aging Study (1987–2004). Experimental gerontology, 39(7), 975-984. https://doi.org/10.1016/j.exger.2004.03.023 DOI: https://doi.org/10.1016/j.exger.2004.03.023

Oyelade, B. O., Jemilohun, A. C., & Aderibigbe, S. A. (2016). Prevalence of erectile dysfunction and possible risk factors among men of South-Western Nigeria: a population based study. Pan African Medical Journal, 24(1).

Pacinella, G., Ciaccio, A. M., & Tuttolomondo, A. (2022). Endothelial dysfunction and chronic inflammation: the cornerstones of vascular alterations in age-related diseases. International Journal of Molecular Sciences, 23(24), 15722. DOI: https://doi.org/10.3390/ijms232415722

Pizzol, D., Smith, L., Fontana, L., Caruso, M. G., Bertoldo, A., Demurtas, J., ... & Veronese, N. (2020). Associations between body mass index, waist circumference and erectile dysfunction: a systematic review and META-analysis. Reviews in Endocrine and Metabolic Disorders, 21, 657-666. DOI: https://doi.org/10.1007/s11154-020-09541-0

Quilter, M., Hodges, L., von Hurst, P., Borman, B., & Coad, J. (2017). Male sexual function in New Zealand: a population-based cross-sectional survey of the prevalence of erectile dysfunction in men aged 40–70 years. The journal of sexual medicine, 14(7), 928-936. DOI: https://doi.org/10.1016/j.jsxm.2017.05.011

Rübsam, A., Parikh, S., & Fort, P. E. (2018). Role of inflammation in diabetic retinopathy. International journal of molecular sciences, 19(4), 942. DOI: https://doi.org/10.3390/ijms19040942

Saffati, G., Seyan, Z., Rendon, D. O., Almuhaideb, M., Hinojosa-Gonzalez, D. E., Kronstedt, S., & Khera, M. (2025). Erectile dysfunction as a holistic indicator of well-being: a narrative review. Sexual Medicine Reviews, 13(1), 11-19. DOI: https://doi.org/10.1093/sxmrev/qeae066

Tarnutzer, A. A., Lee, S. H., Robinson, K. A., Wang, Z., Edlow, J. A., & Newman-Toker, D. E. (2017). ED misdiagnosis of cerebrovascular events in the era of modern neuroimaging: a meta-analysis. Neurology, 88(15), 1468-1477. DOI: https://doi.org/10.1212/WNL.0000000000003814

Terentes-Printzios, D., Ioakeimidis, N., Rokkas, K., & Vlachopoulos, C. (2022). Interactions between erectile dysfunction, cardiovascular disease and cardiovascular drugs. Nature Reviews Cardiology, 19(1), 59-74. DOI: https://doi.org/10.1038/s41569-021-00593-6

Vovk, A., Wild, F., Guest, W., & Kuula, T. (2018). Simulator sickness in augmented reality training using the Microsoft HoloLens. In Proceedings of the 2018 CHI conference on human factors in computing systems (pp. 1-9). DOI: https://doi.org/10.1145/3173574.3173783

Zhang, F., Li, Y., Shi, Z., & Wang, A. (2024). Sexual experience in patients with coronary heart disease: a descriptive phenomenological study. Scientific Reports, 14(1), 9968. DOI: https://doi.org/10.1038/s41598-024-60496-7

Published

24-05-2025

How to Cite

Niema, E., Albaghlany, R., & Mansor, A. (2025). The prevalence of cardiovascular disease in male patients with type 2 diabetes mellitus and erectile dysfunction, along with an assessment of shared cardiovascular risk factors: CVD prevalence and the risk factors in T2DM males with ED. International Journal of Health Sciences, 9(2), 355–367. https://doi.org/10.53730/ijhs.v9n2.15655

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Peer Review Articles