Protective effects of rosmarinus officinalis extract against scopolamine-induced behavioral disturbances and brain oxidative stress in rats

Authors

  • Smita Verma Patel College of Pharmacy, Madhyanchal Professional University, Ratibad-462042, Bhopal, Madhya Pradesh
  • Pankaj Masih Patel College of Pharmacy, Madhyanchal Professional University, Ratibad-462042, Bhopal, Madhya Pradesh
  • Dharmendra Singh Rajput Patel College of Pharmacy, Madhyanchal Professional University, Ratibad-462042, Bhopal, Madhya Pradesh
  • Naveen Gupta Patel College of Pharmacy, Madhyanchal Professional University, Ratibad-462042, Bhopal, Madhya Pradesh

Keywords:

Rosmarinus officinalis (ROE), Cognitive Functions, Scopolamine, TBARS, Memory

Abstract

Ethnopharmacological relevance: Alzheimer's disease (AD) as the most common type of dementia is affecting the life of many senior individuals around the world. Rosmarinus officinalis (R. officinalis) as a middle east originated plant demonstrated antioxidant and antitumor effects. This plant traditionally used to treat diabetes and hypertension, but its mechanism remains unclear. Aim of the study: In the present study, post-treatment effects of R. officinalis on learning and memory functions, antioxidant cellular defense and oxidative stress were investigated using the scopolamine rat model of AD. Materials and methods: Wistar male rats (170-190 g) were administered Scopolamine, an anti-muscarinic drug, (2 mg/kg) for 10 days followed by R. officinalis extract (200, 300 and 400 mg/kg) and/Piracetam (PR; 1 mg/kg, which were administered before behavioral studies for 10 consecutive days. All the rats were then subjected to Morris water maze (MWM) task. Biochemical parameters of oxidative stress were quantified using the whole brain. Results: Our data showed significant decrease performance in target quadrant in water maze task following administration of scopolamine (SCOP). Also, R. officinalis and PR; did not induce any neurotoxicity and hepatotoxic effects at the highest utilized doses in healthy rats.

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Published

02-02-2024

How to Cite

Verma, S., Masih, P., Rajput, D. S., & Gupta, N. (2024). Protective effects of rosmarinus officinalis extract against scopolamine-induced behavioral disturbances and brain oxidative stress in rats. International Journal of Health Sciences, 8(S1), 209–222. Retrieved from http://www.sciencescholar.us/journal/index.php/ijhs/article/view/14713

Issue

Vol. 8 No. S1 (2024)

Section

Peer Review Articles
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