Incidence of dry eye in rheumatoid arthritis and associated macular toxicity due to drug

Authors

  • Bhagyajyothi B K Associate Professor, Department of Ophthalmology, JNMC KLE Belagavi
  • Surabhi Beniwal Post graduate student, Department of Ophthalmology, JNMC KLE Belagavi
  • Dhruv Goyal Post graduate student, Department of Ophthalmology, JNMC KLE Belagavi
  • Mitali Mangoli Post graduate student, Department of Ophthalmology, JNMC KLE Belagavi
  • Shivanand Bubanale Professor and Head, Department of Ophthalmology, JNMC KLE Belagavi
  • Smitha K S Professor, Department of Ophthalmology, JNMC KLE Belagavi
  • Chethana Warad Assistant Professor, Department of Ophthalmology, JNMC KLE Belagavi

Keywords:

rheumatoid arthritis, dry eye syndromes, DAS, Schirmer test, TBUT, OSDI, hydroxychloroquine, retinopathy

Abstract

Background: “Dry eye” is used to describe a variety of conditions with diverse origins that affect the tear film and/or the ocular surface. [1]. Although it is well established that dry eye is frequently associated with Rheumatoid Arthritis (RA), the correlation between the severity of dry eye and the activity of RA is unclear. Patients suffering from RA commonly develop dry eye secondary to lymphocytic and plasma cell infiltrate of the lacrimal gland that lead to destruction of acini in the lacrimal glands Aim: To evaluate the incidence of dry eye in rheumatoid arthritis (RA) patients, and to investigate the effect of the routine Hydroxychloroquine drug therapy on the retina. Methods: In 75 RA patients, the severity of dry eye was assessed by the Schirmer I test, tear break-up time, rose Bengal staining, fluorescein staining and OSDI scoring. The RA activity was evaluated by the duration of the disease, Disease Activity Score (DAS)-28 score, Rheumatoid Factor, hs CRP and ESR levels. Results: The incidence of dry eye increased with the duration of rheumatoid arthritis. A strong correlation between RA factor levels and severity of dry eye was seen. OSDI was a reliable measure of dry eye symptoms. 

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Published

18-10-2022

How to Cite

Bhagyajyothi, B. K., Beniwal, S., Goyal, D., Mangoli, M., Bubanale, S., Smitha, K. S., & Warad, C. (2022). Incidence of dry eye in rheumatoid arthritis and associated macular toxicity due to drug. International Journal of Health Sciences, 6(S8), 5339–5347. Retrieved from http://www.sciencescholar.us/journal/index.php/ijhs/article/view/13449

Issue

Vol. 6 No. S8 (2022)

Section

Peer Review Articles
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